Cytotoxic T-cell response to acetaldehyde-pulsed cells in alcoholic liver disease.
نویسندگان
چکیده
منابع مشابه
Acetaldehyde adducts in alcoholic liver disease
Chronic alcohol abuse causes liver disease that progresses from simple steatosis through stages of steatohepatitis, fibrosis, cirrhosis, and eventually hepatic failure. In addition, chronic alcoholic liver disease (ALD), with or without cirrhosis, increases risk for hepatocellular carcinoma (HCC). Acetaldehyde, a major toxic metabolite, is one of the principal culprits mediating fibrogenic and ...
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BACKGROUND Chronic ingestion of ethanol increases acetaldehyde and leads to the production of acetaldehyde-derived advanced glycation end-products (AA-AGE). We evaluated the toxicity of AA-AGE on hepatocytes and studied the role of AA-AGE in the pathogenesis of alcoholic liver disease (ALD). METHODS Rat hepatocyte cultures were treated with N-ethyllysine (NEL) or AA-AGE and the cell viability...
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In order to determine the specificity of abnormalities of alcohol metabolism in patients with alcoholic liver disease, blood acetaldehyde concentrations after oral ethanol challenge and the activities of alcohol metabolising enzymes in liver biopsy samples have been determined in patients with alcoholic liver disease and a wide variety of non-alcoholic liver disorders. Significant decreases in ...
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ژورنال
عنوان ژورنال: Kanzo
سال: 1988
ISSN: 0451-4203,1881-3593
DOI: 10.2957/kanzo.29.1654